RISK OF ARTERIAL HYPERTENSION IN THE POPULATION OF WESTERN UKRAINE DEPENDING ON CLINICAL, GENDER, AND MOLECULAR-GENETIC PREDICTORS

Introduction. Nowadays, the number of adults with hypertension has doubled worldwide from 650 million in 1990 to 1.28 billion 2019, mostly low- and middle-income countries. Late diagnosis disease leads increased morbidity, target organs damage, early disability. Therefore, risk factors stratification for patients is an important task modern medicine. Objective. To study essential arterial (EAH) population Western Ukraine, taking into account anthropometric, clinical demographic, gender genetic (NOS3, rs2070744 GNB3, rs5443). Materials methods. 100 EAH 48 apparently healthy individuals (the control group) participated study. All participants underwent laboratory examinations. Risk included a burdened anamnesis cardiovascular (CVD), type 2 diabetes mellitus (DM2), waist circumference (WC), hip (HC), waist-to-hip ratio (WHR), body mass index (BMI) men (M) women (W). GNB3 (rs5443) NOS3 (rs2070744) genes genotyping was performed by real-time PCR. Results. The generally due CVD heredity regardless genotypes almost 3–4.5 times, most pronounced correlation mutation C-allele carriers gene T-allele [OR = 3.10–4.29; OR (95% CI): 1.03–13.77; p ≤ 0.041–0.005], DM2 – 7–14 times 7.14–14.25; 1.0–127.2; 0.043–0.006], WC (M > 102 cm, W 88 cm) 3.5–17 3.45–16.67; 1.06–66.09; 0.035–0.0001]. Gender analysis confirmed association between elevated WHR, but only (> 0.85 U) 4.5–51 4.44–51.33; 1.10–346.9; 0.036–0.0001] TT‑genotype CC-genotype gene. Augmented BMI 25.0 kg/m2) also enhanced more than 6–9 6.29–9.0; 1.0–83.07; 0.034–0.011], TT genotype CC 5 4.80; 1.25–18.42; 0.019] 11.5 11.50; 2.01–65.91; 0.004], respectively. Conclusions. Ukraine factors, DM2, BMI, women,